Which two nations represent current regional nuclear security issues for the United States?

The two nations that represent current regional nuclear security issues for the United States are Iran and Pakistan.

Iran has been in the spotlight due to its controversial nuclear program, which has raised concerns in the international community about the potential development of nuclear weapons. The Joint Comprehensive Plan of Action (JCPOA), commonly known as the Iran nuclear deal, aimed to limit Iran's nuclear capabilities in exchange for sanctions relief. However, the deal's instability and Iran's subsequent actions have kept it a focal point of concern regarding nuclear proliferation in an already volatile region.

Pakistan, on the other hand, is significant because it possesses an extensive nuclear arsenal and has a history of tension with India, another nuclear-armed state. The relationship between Pakistan and India is particularly precarious due to ongoing territorial disputes and military conflicts, which could potentially escalate into a nuclear confrontation.

These concerns make Iran and Pakistan critical focal points for U.S. nuclear security policy and diplomatic efforts in the realm of non-proliferation and regional stability.